HORDB

ID: hor005718
Uniprot ID: Q9I9D3
Protein name: Neuropeptide Y
Gene name: npy
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ictalurus (genus), Ictaluridae (family), Siluroidei (suborder), Siluriformes (order), Characiphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: YPTKPENPGEDAPVEELAKYYSALRHYINLITRQRY
Length: 36
Propeptide: MRPRANVCVGWAACILLVVCLCVLAEGYPTKPENPGEDAPVEELAKYYSALRHYINLITRQRYGKRSNTDVLTPDLLFGEAEIRLQSRYDDPLMG
Signal peptide: MRPRANVCVGWAACILLVVCLCVLAEG
Modification: T36 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: npy2r
Target Unid: A0A2D0QDQ4
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005718_AF2.pdb

hor005718_ESM.pdb

Mass:	492126	Formula:	C195H296N52O58
Absent amino acids:	CFMW	Common amino acids:	Y
pI:	7.52	Basic residues:	6
Polar residues:	11	Hydrophobic residues:	9
Hydrophobicity:	-105.56	Boman Index:	-8953
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	70.56
Instability Index:	6768.33	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86